Neuroprotection of midbrain dopaminergic cells in MPTP‐treated mice after near‐infrared light treatment
Identifieur interne : 007231 ( Main/Exploration ); précédent : 007230; suivant : 007232Neuroprotection of midbrain dopaminergic cells in MPTP‐treated mice after near‐infrared light treatment
Auteurs : Victoria E. Shaw [Australie] ; Sharon Spana [Australie] ; Keyoumars Ashkan [Royaume-Uni] ; Alim-Louis Benabid [France] ; Jonathan Stone [Australie] ; Gary E. Baker [Royaume-Uni] ; John Mitrofanis [Australie]Source :
- Journal of Comparative Neurology [ 0021-9967 ] ; 2010-01-01.
Descripteurs français
- Wicri :
- topic : Neurologie.
English descriptors
- KwdEn :
- Animal models, Anova test, Bjorklund, Cell death, Cell number, Columns show, Comp neurol, Comparative neurology research, Coronal sections, Cytochrome oxidase, Degeneration, Different groups, Dopamine, Dopaminergic, Dopaminergic cell group, Dopaminergic cells, Dopaminergic cells figure, Dorsal, Dorsal hypothalamus, Dos, Eells, Error bars, Experimental groups, Fitzpatrick, Future studies, Hydroxylase, Laser, Lateral, Liang, Light treatment, Little variability, Midbrain, Midbrain dopaminergic cells, Milder mptp regimen, Mitochondrial, Mitochondrial dysfunction, Mitrofanis, Mouse brain, Mptp, Mptp dose regimen, Mptp group, Mptp injection, Mptp injections, Mptp insult, Mptp regimen, Mptp regimens, Mptp toxicity, Mptp treatment, Multiple comparison test, Neurol, Neurology, Neuron, Neuroprotection, Neuroprotective, Neuroprotective effects, Neurosci, Neuroscience, Nigra, Oron, Other groups, Parkinsonian, Parkinsonian cases, Parkinsonian insult, Paxinos, Photobiomodulation, Photomicrograph, Previous studies, Regimen, Room temperature, Saline injections, Saline mptp, Same group, Standard error, Stronger regimen, Substantia, Substantia nigra pars compacta, Subthalamic nucleus, Systems neuroscience, Systems neuroscience neuroprotection, Total number, Toxicity, Toxin, Tyrosine hydroxylase, Ventral, Ventral sector, Whelan, Wound healing, Zona incerta.
- Teeft :
- Animal models, Anova test, Bjorklund, Cell death, Cell number, Columns show, Comp neurol, Comparative neurology research, Coronal sections, Cytochrome oxidase, Degeneration, Different groups, Dopamine, Dopaminergic, Dopaminergic cell group, Dopaminergic cells, Dopaminergic cells figure, Dorsal, Dorsal hypothalamus, Dos, Eells, Error bars, Experimental groups, Fitzpatrick, Future studies, Hydroxylase, Laser, Lateral, Liang, Light treatment, Little variability, Midbrain, Midbrain dopaminergic cells, Milder mptp regimen, Mitochondrial, Mitochondrial dysfunction, Mitrofanis, Mouse brain, Mptp, Mptp dose regimen, Mptp group, Mptp injection, Mptp injections, Mptp insult, Mptp regimen, Mptp regimens, Mptp toxicity, Mptp treatment, Multiple comparison test, Neurol, Neurology, Neuron, Neuroprotection, Neuroprotective, Neuroprotective effects, Neurosci, Neuroscience, Nigra, Oron, Other groups, Parkinsonian, Parkinsonian cases, Parkinsonian insult, Paxinos, Photobiomodulation, Photomicrograph, Previous studies, Regimen, Room temperature, Saline injections, Saline mptp, Same group, Standard error, Stronger regimen, Substantia, Substantia nigra pars compacta, Subthalamic nucleus, Systems neuroscience, Systems neuroscience neuroprotection, Total number, Toxicity, Toxin, Tyrosine hydroxylase, Ventral, Ventral sector, Whelan, Wound healing, Zona incerta.
Abstract
This study explores whether near‐infrared (NIr) light treatment neuroprotects dopaminergic cells in the substantia nigra pars compacta (SNc) and the zona incerta‐hypothalamus (ZI‐Hyp) from degeneration in 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐treated mice. BALB/c albino mice were divided into four groups: 1) Saline, 2) Saline‐NIr, 3) MPTP, 4) MPTP‐NIr. The injections were intraperitoneal and they were followed immediately by NIr light treatment (or not). Two doses of MPTP, mild (50 mg/kg) and strong (100 mg/kg), were used. Mice were perfused transcardially with aldehyde fixative 6 days after their MPTP treatment. Brains were processed for tyrosine hydroxylase (TH) immunochemistry. The number of TH+ cells was estimated using the optical fractionator method. Our major finding was that in the SNc there were significantly more dopaminergic cells in the MPTP‐NIr compared to the MPTP group (35%–45%). By contrast, in the ZI‐Hyp there was no significant difference in the numbers of cells in these two groups. In addition, our results indicated that survival in the two regions after MPTP insult was dose‐dependent. In the stronger MPTP regime, the magnitude of loss was similar in the two regions (≈60%), while in the milder regime cell loss was greater in the SNc (45%) than ZI‐Hyp (≈30%). In summary, our results indicate that NIr light treatment offers neuroprotection against MPTP toxicity for dopaminergic cells in the SNc, but not in the ZI‐Hyp. J. Comp. Neurol. 518:25–40, 2010. © 2009 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/cne.22207
Affiliations:
- Australie, France, Royaume-Uni
- Angleterre, Grand Londres, Nouvelle-Galles du Sud
- Londres, Sydney
- Université de Sydney
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Le document en format XML
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of Sydney 2006</wicri:regionArea><wicri:noRegion>University of Sydney 2006</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Comparative Neurology</title><idno type="ISSN">0021-9967</idno><idno type="eISSN">1096-9861</idno><imprint><biblScope unit="vol">518</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="25">25</biblScope><biblScope unit="page" to="40">40</biblScope><biblScope unit="page-count">16</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-01-01">2010-01-01</date></imprint><idno type="ISSN">0021-9967</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0021-9967</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal models</term><term>Anova test</term><term>Bjorklund</term><term>Cell death</term><term>Cell number</term><term>Columns show</term><term>Comp neurol</term><term>Comparative neurology research</term><term>Coronal sections</term><term>Cytochrome oxidase</term><term>Degeneration</term><term>Different groups</term><term>Dopamine</term><term>Dopaminergic</term><term>Dopaminergic cell group</term><term>Dopaminergic cells</term><term>Dopaminergic cells figure</term><term>Dorsal</term><term>Dorsal hypothalamus</term><term>Dos</term><term>Eells</term><term>Error bars</term><term>Experimental groups</term><term>Fitzpatrick</term><term>Future studies</term><term>Hydroxylase</term><term>Laser</term><term>Lateral</term><term>Liang</term><term>Light treatment</term><term>Little variability</term><term>Midbrain</term><term>Midbrain dopaminergic cells</term><term>Milder mptp regimen</term><term>Mitochondrial</term><term>Mitochondrial dysfunction</term><term>Mitrofanis</term><term>Mouse brain</term><term>Mptp</term><term>Mptp dose regimen</term><term>Mptp group</term><term>Mptp injection</term><term>Mptp injections</term><term>Mptp insult</term><term>Mptp regimen</term><term>Mptp regimens</term><term>Mptp toxicity</term><term>Mptp treatment</term><term>Multiple comparison test</term><term>Neurol</term><term>Neurology</term><term>Neuron</term><term>Neuroprotection</term><term>Neuroprotective</term><term>Neuroprotective effects</term><term>Neurosci</term><term>Neuroscience</term><term>Nigra</term><term>Oron</term><term>Other groups</term><term>Parkinsonian</term><term>Parkinsonian cases</term><term>Parkinsonian insult</term><term>Paxinos</term><term>Photobiomodulation</term><term>Photomicrograph</term><term>Previous studies</term><term>Regimen</term><term>Room temperature</term><term>Saline injections</term><term>Saline mptp</term><term>Same group</term><term>Standard error</term><term>Stronger regimen</term><term>Substantia</term><term>Substantia nigra pars compacta</term><term>Subthalamic nucleus</term><term>Systems neuroscience</term><term>Systems neuroscience neuroprotection</term><term>Total number</term><term>Toxicity</term><term>Toxin</term><term>Tyrosine hydroxylase</term><term>Ventral</term><term>Ventral sector</term><term>Whelan</term><term>Wound healing</term><term>Zona incerta</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Animal models</term><term>Anova test</term><term>Bjorklund</term><term>Cell death</term><term>Cell number</term><term>Columns show</term><term>Comp neurol</term><term>Comparative neurology research</term><term>Coronal sections</term><term>Cytochrome oxidase</term><term>Degeneration</term><term>Different groups</term><term>Dopamine</term><term>Dopaminergic</term><term>Dopaminergic cell group</term><term>Dopaminergic cells</term><term>Dopaminergic cells figure</term><term>Dorsal</term><term>Dorsal hypothalamus</term><term>Dos</term><term>Eells</term><term>Error bars</term><term>Experimental groups</term><term>Fitzpatrick</term><term>Future studies</term><term>Hydroxylase</term><term>Laser</term><term>Lateral</term><term>Liang</term><term>Light treatment</term><term>Little variability</term><term>Midbrain</term><term>Midbrain dopaminergic cells</term><term>Milder mptp regimen</term><term>Mitochondrial</term><term>Mitochondrial dysfunction</term><term>Mitrofanis</term><term>Mouse brain</term><term>Mptp</term><term>Mptp dose regimen</term><term>Mptp group</term><term>Mptp injection</term><term>Mptp injections</term><term>Mptp insult</term><term>Mptp regimen</term><term>Mptp regimens</term><term>Mptp toxicity</term><term>Mptp treatment</term><term>Multiple comparison test</term><term>Neurol</term><term>Neurology</term><term>Neuron</term><term>Neuroprotection</term><term>Neuroprotective</term><term>Neuroprotective effects</term><term>Neurosci</term><term>Neuroscience</term><term>Nigra</term><term>Oron</term><term>Other groups</term><term>Parkinsonian</term><term>Parkinsonian cases</term><term>Parkinsonian insult</term><term>Paxinos</term><term>Photobiomodulation</term><term>Photomicrograph</term><term>Previous studies</term><term>Regimen</term><term>Room temperature</term><term>Saline injections</term><term>Saline mptp</term><term>Same group</term><term>Standard error</term><term>Stronger regimen</term><term>Substantia</term><term>Substantia nigra pars compacta</term><term>Subthalamic nucleus</term><term>Systems neuroscience</term><term>Systems neuroscience neuroprotection</term><term>Total number</term><term>Toxicity</term><term>Toxin</term><term>Tyrosine hydroxylase</term><term>Ventral</term><term>Ventral sector</term><term>Whelan</term><term>Wound healing</term><term>Zona incerta</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Neurologie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study explores whether near‐infrared (NIr) light treatment neuroprotects dopaminergic cells in the substantia nigra pars compacta (SNc) and the zona incerta‐hypothalamus (ZI‐Hyp) from degeneration in 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐treated mice. BALB/c albino mice were divided into four groups: 1) Saline, 2) Saline‐NIr, 3) MPTP, 4) MPTP‐NIr. The injections were intraperitoneal and they were followed immediately by NIr light treatment (or not). Two doses of MPTP, mild (50 mg/kg) and strong (100 mg/kg), were used. Mice were perfused transcardially with aldehyde fixative 6 days after their MPTP treatment. Brains were processed for tyrosine hydroxylase (TH) immunochemistry. The number of TH+ cells was estimated using the optical fractionator method. Our major finding was that in the SNc there were significantly more dopaminergic cells in the MPTP‐NIr compared to the MPTP group (35%–45%). By contrast, in the ZI‐Hyp there was no significant difference in the numbers of cells in these two groups. In addition, our results indicated that survival in the two regions after MPTP insult was dose‐dependent. In the stronger MPTP regime, the magnitude of loss was similar in the two regions (≈60%), while in the milder regime cell loss was greater in the SNc (45%) than ZI‐Hyp (≈30%). In summary, our results indicate that NIr light treatment offers neuroprotection against MPTP toxicity for dopaminergic cells in the SNc, but not in the ZI‐Hyp. J. Comp. Neurol. 518:25–40, 2010. © 2009 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Nouvelle-Galles du Sud</li></region><settlement><li>Londres</li><li>Sydney</li></settlement><orgName><li>Université de Sydney</li></orgName></list><tree><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Shaw, Victoria E" sort="Shaw, Victoria E" uniqKey="Shaw V" first="Victoria E." last="Shaw">Victoria E. Shaw</name></region><name sortKey="Mitrofanis, John" sort="Mitrofanis, John" uniqKey="Mitrofanis J" first="John" last="Mitrofanis">John Mitrofanis</name><name sortKey="Mitrofanis, John" sort="Mitrofanis, John" uniqKey="Mitrofanis J" first="John" last="Mitrofanis">John Mitrofanis</name><name sortKey="Mitrofanis, John" sort="Mitrofanis, John" uniqKey="Mitrofanis J" first="John" last="Mitrofanis">John Mitrofanis</name><name sortKey="Spana, Sharon" sort="Spana, Sharon" uniqKey="Spana S" first="Sharon" last="Spana">Sharon Spana</name><name sortKey="Stone, Jonathan" sort="Stone, Jonathan" uniqKey="Stone J" first="Jonathan" last="Stone">Jonathan Stone</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Ashkan, Keyoumars" sort="Ashkan, Keyoumars" uniqKey="Ashkan K" first="Keyoumars" last="Ashkan">Keyoumars Ashkan</name></region><name sortKey="Baker, Gary E" sort="Baker, Gary E" uniqKey="Baker G" first="Gary E." last="Baker">Gary E. Baker</name></country><country name="France"><noRegion><name sortKey="Benabid, Alim Ouis" sort="Benabid, Alim Ouis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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